Product Number	B3206
Purity / Analysis Method	>98.0%(HPLC)(N)
Molecular Formula / Molecular Weight	C₁₈H₁₄F₄N₂O₄S = 430.37
Physical State (20 deg.C)	Solid
Storage Temperature	Room Temperature (Recommended in a cool and dark place, <15°C)
Packaging and Container	1G-Glass Bottle with Plastic Insert (View image)
CAS RN	90357-06-5
Reaxys Registry Number	5364666
PubChem Substance ID	172088993
Merck Index (14)	1200
MDL Number	MFCD00869971

Specifications

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(with Total Nitrogen)	min. 98.0 %
Melting point	194.0 to 198.0 °C

Properties (reference)

Melting Point	196 °C
Maximum Absorption Wavelength	270 nm (CH₃CN)

GHS

Pictogram
Signal Word	Danger
Hazard Statements	H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child.
Precautionary Statements	P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P405 : Store locked up.

Related Laws:

RTECS#

TX1413500

Transport Information:

Application

Bicalutamide: A Non-Steroidal Androgen Receptor Antagonist

Bicalutamide (ICI 176334) and flutamide [F0663] are non-steroidal androgen receptor antagonists with antiandrogenic activity. Testosterone [T0027], the most important androgen, converted to 5α-dihydrotestosterone (DHT) [A0462] by 5α-reductase type 2 which reduces the 4,5-double bond of testosterone in prostate cells. DHT has two or three times greater androgen receptor (AR) affinity than testosterone. Upon DHT binding, the AR undergoes a conformational change and releases heat shock proteins (HSPs), resulting in mRNA expression and prostate cell proliferation. Bicalutamide acts as a potent and highly selective competitive antagonist of the AR, blocks the conversion of testosterone to DHT, and inhibits the proliferation of prostate cells. Bicalutamide and flutamide are used for the treatment of prostate cancer and other androgen-dependent conditions. For your reference, [C3607] is a synthetic intermediate of bicalutamide. (The product is for research purpose only.)

References

ICI 176,334: a novel non-steroidal, peripherally selective antiandrogen
- B. J. A. Furr, B. Valcaccia, B. Curry, J. R. Woodburn, G. Chesterson, H. Tucker, J. Endocrinol. 1987, 113, R7.
Novel Mutations of Androgen Receptor: A Possible Mechanism of Bicalutamide Withdrawal Syndrome
- T. Hara, J.-I. Miyazaki, H. Araki, M. Yamaoka, N. Kanzaki, M. Kusaka, M. Miyamoto, Cancer Res. 2003, 63, 149.
Switch from antagonist to agonist of the androgen receptor blocker bicalutamide is associated with prostate tumour progression in a new model system
- Z. Culig, J. Hoffmann, M. Erdel, I. E. Eder, A. Hobisch, A. Hittmair, G. Bartsch, G. Utermann, M. R. Schneider, K. Parczyk, H. Klocker, Br. J. Cancer 1999, 81, 242.
The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens
- J. Veldscholte, C .A. Berrevoets, C. Ris-Stalpers, G. G. J. M. Kuiper, G. Jenster, J. Trapman, A. O. Brinkmann, E. Mulder, J. Steroid Biochem. Mol. Biol. 1992, 41, 665.
Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor
- D. Masiello, S. Cheng, G. J. Bubley, M. L. Lu, S. P. Balk, J. Biol. Chem. 2002, 277, 26321.
Isolation and characterization of process related impurities and degradation products of bicalutamide and development of RP-HPLC method for impurity profile study
- R. N. Rao, A. N. Raju, R. Narsimha, J. Pharm. Biomed. Anal. 2008, 46, 505.

PubMed Literature

Size	Unit Price	Hyderabad	Japan*	Quantity
200MG	₹3,500.00	1	13
1G	₹8,400.00	4	≥40

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CAS RN: 90357-06-5 | Product Number: B3206

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CAS RN: 90357-06-5 | Product Number: B3206

Bicalutamide

References

Articles/Brochures

Safety Data Sheet (SDS)

Specifications

C of A & Other Certificates

Sample C of A

Analytical Charts

Other Documents

Product Categories

Life Science

Life Science

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