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CAS RN: 379231-04-6 | Product Number: A3611
Saracatinib
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- AZD0530
- N-[5-Chlorobenzo[d][1,3]dioxol-4-yl]-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]quinazolin-4-amine
- N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)-4-quinazolinamine
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
₹11,500.00
|
2 | 13 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A3611 |
| Purity / Analysis Method | >95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__7H__3__2ClN__5O__5 = 542.03 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 379231-04-6 |
| Reaxys Registry Number | 10742554 |
| MDL Number | MFCD09832698 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 144 °C |
GHS
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Application
Saracatinib: A Highly Selective Dual Inhibitor of c-Src and Abl Tyrosine Kinases
Saracatinib (AZD0530) is an oral, highly selective dual inhibitor of c-Src and Abl tyrosine kinases.1-3) Saracatinib has been shown to inhibit tumor growth in a c-Src-transfected 3T3 fibroblast xenograft model in vivo.1) However, while saracatinib was well tolerated in humans, there were no responses and it did not show sufficient efficacy in cancer patients.4) More recently, saracatinib has been investigated in other indications, including Alzheimer's disease.5) (The product is for research purpose only.)
References
- 1) N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a Novel, Highly Selective, Orally Available, Dual-Specific c-Src/Abl Kinase Inhibitor
- 2) Novel dual Src/Abl inhibitors for hematologic and solid malignancies
- 3) Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors (a review)
- 4) Phase II study of saracatinib (AZD0530) in patients with previously treated metastatic colorectal cancer
- 5) Fyn inhibition rescues established memory and synapse loss in Alzheimer mice
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