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CAS RN: 319460-85-0 | Product Number: A3479
Axitinib
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Purity: >95.0%(T)(HPLC)
Synonyms:
- (E)-N-Methyl-2-[[3-[2-(pyridin-2-yl)vinyl]-1H-indazol-6-yl]thio]benzamide
- N-Methyl-2-[[3-[(1E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
₹15,000.00
|
Contact Us | 18 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A3479 |
| Purity / Analysis Method | >95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__1__8N__4OS = 386.47 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 319460-85-0 |
| Reaxys Registry Number | 11333336 |
| MDL Number | MFCD09837898 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Melting point | 217.0 to 221.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 219 °C |
| Maximum Absorption Wavelength | 335(DMSO) nm |
| Solubility in water | Insoluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | CV5586363 |
Transport Information:
Application
Axitinib: A Potent and Selective Inhibitor of VEGFR Tyrosine Kinases -1, -2, and -3
Axitinib (AG-013736), a small molecule indazole derivative, is an oral, potent tyrosine kinase receptor inhibitor, which selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2, and -3. These receptors are implicated in pathologic angiogenesis, tumor growth, and cancer progression. Axitinib is shown to inhibit cellular autophosphorylation of VEGF receptors and tumor growth. (The product is for research purpose only.)
References
- Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3.
- Axitinib for the management of metastatic renal cell carcinoma (a review)
- Clinical Pharmacology of Axitinib (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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