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CAS RN: 94749-08-3 | Product Number: A3190

Salmeterol Xinafoate


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 4-[1-Hydroxy-2-[[6-(4-phenylbutoxy)hexyl]amino]ethyl]-2-(hydroxymethyl)phenol 1-Hydroxy-2-naphthoate
Product Documents:
250MG
₹12,200.00
1   13  
1G
₹14,800.00
2   9  

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Product Number A3190
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__5H__3__7NO__4·C__1__1H__8O__3 = 603.76 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
Packaging and Container 1G-Glass Bottle with Plastic Insert (View image),  250MG-Glass Bottle with Plastic Insert (View image)
CAS RN 94749-08-3
Related CAS RN 89365-50-4
Reaxys Registry Number 9833043
PubChem Substance ID 354335558
Merck Index (14) 8337
MDL Number

MFCD00897708

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 %(total of Ion-Pair)
Purity(Neutralization titration) min. 98.0 %
Properties (reference)
Melting Point 138 °C(dec.)
Solubility in water Insoluble
Solubility (soluble in) Methanol
Solubility (slightly sol. in) Ethanol
Solubility (insoluble in) Diethyl ether
GHS
Related Laws:
RTECS# QJ1970500
Transport Information:
Application
Salmeterol Xinafoate: A Selective and Long-Acting β2-Adrenergic Receptor Agonist

A3190

Salmeterol xinafoate is a selective and long-acting β2-adrenergic receptor agonist. In vitro and in vivo studies demonstrate that salmeterol is selective for β2- adrenergic receptors compared with isoproterenol [I0260], which has approximately equal agonist activity on β1 and β2- adrenergic receptors. The pharmacologic effects of β2-adrenergic receptor agonist agents, including salmeterol, attributable to stimulation of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) [A0157 (2Na salt)] to cyclic-3’,5’-adenosine monophosphate (c-AMP) [A2381, A2112 (Na salt)]. Increased c-AMP levels cause relaxation of bronchial smooth muscle and inhibition of release of inflammatory mediators from cells, especially from mast cells.
The mechanism of action for long-acting is explained as follows. Salmeterol consists of a saligenin ethanolamine “head” with a large lipophilic “tail” or side chain. Because of the side chain is anchored at the exo-site, the active “head” portion continually attaches to and detaches from the receptor site. (The product is for research purpose only.)

References


PubMed Literature


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