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CAS RN: 138112-76-2 | Product Number: A2606
Agomelatine
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Purity: >98.0%(HPLC)(N)
Synonyms:
- N-[2-(7-Methoxy-1-naphthalenyl)ethyl]acetamide
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
₹9,400.00
|
Contact Us | ≥40 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A2606 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__5H__1__7NO__2 = 243.31 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 138112-76-2 |
| Reaxys Registry Number | 5813634 |
| PubChem Substance ID | 253661921 |
| Merck Index (14) | 190 |
| MDL Number | MFCD00916659 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 108.0 to 112.0 °C |
Properties (reference)
| Melting Point | 110 °C |
| Solubility (soluble in) | Methanol |
GHS
Related Laws:
| RTECS# | AC5956323 |
Transport Information:
Application
Agomelatine: A Melatonergic MT1 and MT2 Receptor Agonist with Serotonin 5-HT2C Receptor Antagonist Activity
Agomelatine is a melatonergic MT1 and MT2 receptor agonist with serotonin 5-HT2C receptor antagonist activity. Stimulation of melatonergic (MT1 and MT2) receptors in suprachiasmatic nucleus of hypothalamus by agomelatine leads to the restoration of disturbed circadian rhythm. Selective binding to serotonin 5HT2C receptors by agomelatine leads to an increase in norepinephrine [A0906(Bitartrate)] and dopamine [A0305(Hydrochloride)] levels.
References
- Novel naphthalenic ligands with high affinity for the melatonin receptor
- The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways
- Effect of Agomelatine in the Chronic Mild Stress Model of Depression in the Rat
- Agomelatine, the first melatonergic antidepressant: discovery, characterization and development
- A systematic, updated review on the antidepressant agomelatine focusing on its melatonergic modulation
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