Published TCIMAIL newest issue No.197
Maximum quantity allowed is 999
Please select the quantity
Cyclooxygenase (COX) Inhibitor: Flurbiprofen
No.178(July 2018)
Flurbiprofen (1) functions as a cyclooxygenase (COX) inhibitors and inhibits COX-1 and COX-2 with the IC50s of 0.1 μM and 0.4 μM, respectively.1) 1 exists as a racemic mixture of their enantiomeric form and the S-isomer is a more potent inhibitor of COX isoenzymes than the R-isomer.2,3) 1 is also widely known as a non-steroidal anti-inflammatory drug (NSAID).1) Furthermore, 1 maintains the self-renewal and pluripotency of human embryonic stem cells.4,5)
* Human recombinant COX-1 and COX-2 were used in the reference 1.
This product is for research purpose only.
References
- 1)Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase
- 2)Stoichiometric and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents
- 3)Flurprofen and enantiomers in ophthalmic solution tested as inhibitors of prostanoid synthesis in human blood
- 4)High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells
- 5)Histone modification profiling reveals differential signatures associated with human embryonic stem cell self-renewal and differentiation
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.