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CAS RN: 58970-76-6 | Product Number: U0111
Ubenimex
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Purity: >98.0%(HPLC)
Synonyms:
- N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 250MG |
122,00 €
|
1 | 25 |
| 1G |
379,00 €
|
1 | 6 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | U0111 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__2__4N__2O__4 = 308.38 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 58970-76-6 |
| Reaxys Registry Number | 4704312 |
| PubChem Substance ID | 468593079 |
| Merck Index (14) | 9842 |
| MDL Number | MFCD00083262 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Specific rotation [a]20/D | -15.0 to -20.0 deg(C=1, 1mol/L HCl) |
Properties (reference)
| Melting Point | 215 °C(dec.) |
| Specific Rotation | -19° (C=1,1mol/L HCl) |
| Maximum Absorption Wavelength | 268 nm |
| Solubility (soluble in) | Methanol |
| Solubility (insoluble in) | Ethanol, Chloroform, Benzene |
GHS
Related Laws:
| EC Number | 261-529-2 |
| RTECS# | OH2915000 |
Transport Information:
| HS Number | 2924297099 |
Application
Ubenimex: A Competitive and Reversible Protease Inhibitor
Ubenimex (bestatin) is a dipeptide which was originally isolated from a culture filtrate of Streptomyces olivoreticuli. Ubenimex is a competitive and reversible protease inhibitor. It is an inhibitor of leucine aminopeptidase, aminopeptidase B and triamino peptidase, etc, and has been used as an experimental tool in mammals. Ubenimex is also a leukotriene A4 hydrolase (LTA4H) inhibitor, and reportedly suppress tumorigenesis in this animal model.
References
- Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes
- Bestatin as an experimental tool in mammals (a review)
- Leukotriene A4 hydrolase as a target for cancer prevention and therapy
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