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Published TCIMAIL newest issue No.197
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CAS RN: 3424-98-4 | Product Number: T4158
Telbivudine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- L-Thymidine
- 1-(2-Deoxy-β-L-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
- 1-[(2S,4R,5S)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 100MG |
€98.00
|
Contact Us | 12 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T4158 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__4N__2O__5 = 242.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 3424-98-4 |
| Reaxys Registry Number | 754297 |
| MDL Number | MFCD02683612 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 186.0 to 190.0 °C |
| Specific rotation | -16.0 to -20.0 deg(C=1, water) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 188 °C |
GHS
Related Laws:
| RTECS# | UV9048500 |
Transport Information:
| HS Number | 2934999090 |
Application
Telbivudine: An L-Nucleoside Analog of Thymidine with Antiviral Activity
Telbivudine is an L-nucleoside analog of thymidine [T0233] with antiviral activity. There are reports that telbivudine is a potent, specific and selective inhibitor of hepatitis B virus (HBV) replication. Telbivudine 5'-triphosphate inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate, thymidine 5'-triphosphate. Incorporation of telbivudine 5'-triphosphate into viral DNA results in DNA chain termination. (The product is for research purpose only.)
Reference
- Antiviral β-L-nucleosides specific for hepatitis B virus infection (a review)
- Telbivudine for the management of chronic hepatitis B virus infection (a review)
- Telbivudine (a review)
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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