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CAS RN: 50679-08-8 | Product Number: T3977
Terfenadine
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Purity: >98.0%(HPLC)
Synonyms:
- α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol
- 1-[4-(tert-butyl)phenyl]-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butan-1-ol
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 1G |
€79.00
|
Contact Us | 6 |
| 5G |
€305.00
|
1 | 7 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3977 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__2H__4__1NO__2 = 471.69 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 50679-08-8 |
| Reaxys Registry Number | 5857899 |
| PubChem Substance ID | 468593048 |
| MDL Number | MFCD00079622 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 146.0 to 150.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 148 °C |
| Maximum Absorption Wavelength | 260(EtOH) nm |
| Solubility in water | Insoluble |
| Degree of solubility in water | 0.0963 mg/l 25 °C |
| Solubility (soluble in) | Methanol, Ethanol |
GHS
Related Laws:
| EC Number | 256-710-8 |
| RTECS# | TM4969000 |
Transport Information:
| HS Number | 2933399990 |
Application
Terfenadine: A Prodrug of Fexofenadine with Selective H1-Receptor Antagonist Activity
Terfenadine is a prodrug of fexofenadine [F0698] (HCl salt) which is a non-sedative antihistamine with selective H1-receptor antagonist activity. Terfenadine is metabolized by intestinal CYP3A4 to fexofenadine which competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently, usual allergic responses as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandins, and leukotriene precursors, are blocked. In addition, it has been reported that terfenadine may reach excessive blood levels when the metabolism is too slow; and which can cause cardiac arrhythmias (prolongation of QT-interval). (The product is for research purpose only.)
References
- Fexofenadine: a review of its use in the management of seasonal allergic rhinitis and chronic idiopathic urticaria
- Terfenadine (A review on description, synthesis, physical properties, analysis, stability, polymorphism and crystal habits, and pharmacokinetics)
Product Documents (Note: Some products will not have analytical charts available.)
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