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Published TCIMAIL newest issue No.197
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CAS RN: 255825-38-8 | Product Number: T3569
N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiouronium Tetrafluoroborate
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Purity: >98.0%(HPLC)
Synonyms:
- TOTT
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 5G |
€88.00
|
1 | 1 |
| 25G |
€282.00
|
1 | 15 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3569 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__6BF__4N__3OS = 313.12 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| CAS RN | 255825-38-8 |
| Reaxys Registry Number | 8455461 |
| PubChem Substance ID | 354335176 |
| MDL Number | MFCD05664718 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 96.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 108 °C(dec.) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
Transport Information:
| HS Number | 2933399990 |
Application
Condensing Agent
Experimental procedure:
A solution of the N-protected amino acid (1 mmol), the amino acid ester hydrochloride (1 mmol), triethylamine (0.28 mL, 2 mmol), and TOTT (1 mmol) in MeCN (10 mL) is stirred at room temperature until disappearance of the free esterified amino acid. Saturated NaCl is added, and the mixture is extracted with AcOEt. The organic layers are washed with 2 mol/L HCl, saturated NaHCO3, and water. The organics are dried (Na2SO4), filtered, and evaporated affording the corresponding peptides.
A solution of the N-protected amino acid (1 mmol), the amino acid ester hydrochloride (1 mmol), triethylamine (0.28 mL, 2 mmol), and TOTT (1 mmol) in MeCN (10 mL) is stirred at room temperature until disappearance of the free esterified amino acid. Saturated NaCl is added, and the mixture is extracted with AcOEt. The organic layers are washed with 2 mol/L HCl, saturated NaHCO3, and water. The organics are dried (Na2SO4), filtered, and evaporated affording the corresponding peptides.
Reference
- 2-Mercaptopyridone 1-Oxide-Based Uronium Salts:? New Peptide Coupling Reagents
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