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Published TCIMAIL newest issue No.197
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CAS RN: 118292-40-3 | Product Number: T3108
Tazarotene
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Purity: >98.0%(GC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 10MG |
€28.00
|
1 | 8 |
| 100MG |
€178.00
|
1 | 32 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3108 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__1NO__2S = 351.46 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 118292-40-3 |
| Reaxys Registry Number | 8159145 |
| PubChem Substance ID | 253662270 |
| Merck Index (14) | 9081 |
| MDL Number | MFCD00867628 |
Specifications
| Appearance | White to Yellow to Green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 102.0 to 106.0 °C |
Properties (reference)
| Melting Point | 105 °C |
GHS
| Hazard Statements | H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
Related Laws:
| RTECS# | US5675100 |
Transport Information:
| HS Number | 2934999090 |
Application
Tazarotene: A Synthetic Retinoic Acid Receptor (RAR)-β and γ Selective Retinoid
Retinoids exert their biological effects through two families of nuclear receptors, retinoic acid receptors (RARs) and retinoid X receptors (RXRs). RAR is a type of nuclear receptor which can also act as a transcription factor that is activated by both all-trans-retinoic acid [R0064] and 9-cis retinoic acid. There are three retinoic acid receptors (RAR-α, β, and γ). Tazarotene is a synthetic RAR-β and γ selective retinoid. Many studies have shown that tazarotene can affect cell proliferation and differentiation through upregulating the expression of tazarotene-induced genes TIG1, TIG2 and TIG3. Tazarotene is used for the treatment of plaque psoriasis and acne vulgaris. (The product is for research purpose only.)
References
- Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin
- Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin
- Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene
- Clinical pharmacokinetics and drug metabolism of tazarotene: a novel topical treatment for acne and psoriasis (a review)
- Tazarotene-induced gene 3 is suppressed in basal cell carcinomas and reversed in vivo by tazarotene application
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