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Published TCIMAIL newest issue No.197
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CAS RN: 133550-30-8 | Product Number: T2962
Tyrphostin AG 490
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 20MG |
€34.00
|
1 | 9 |
| 100MG |
€110.00
|
1 | Contact Us |
| 1G |
€694.00
|
1 | 2 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T2962 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__4N__2O__3 = 294.31 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 133550-30-8 |
| Reaxys Registry Number | 4323263 |
| PubChem Substance ID | 253661829 |
| MDL Number | MFCD00236452 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 215 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| RTECS# | UC6316197 |
Transport Information:
| UN Number | UN3439 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2926907090 |
Application
JAK Inhibitor
References
- 1)The Janus kinases (Jaks)
- 2)Janus kinases: Components of multiple signaling pathways
- 3)Tyrphostines. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases
- 4)Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
- 5)JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response
- 6)Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b of signal transduction and cellular proliferation of antigen-activated human T cells
- 7)JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells
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