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Published TCIMAIL newest issue No.197
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CAS RN: 15318-45-3 | Product Number: T2802
Thiamphenicol
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-[4-(methylsulfonyl)phenyl]-2-propyl]acetamide
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 5G |
€52.00
|
3 | ≥80 |
| 25G |
€174.00
|
2 | 11 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T2802 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__2H__1__5Cl__2NO__5S = 356.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 15318-45-3 |
| Reaxys Registry Number | 2819542 |
| PubChem Substance ID | 135726881 |
| Merck Index (14) | 9301 |
| MDL Number | MFCD00467983 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 164.0 to 168.0 °C |
| Specific rotation [a]20/D | +10.0 to +13.0 deg(C=1, EtOH) |
Properties (reference)
| Melting Point | 166 °C |
| Specific Rotation | 11° (C=1,EtOH) |
| Solubility (soluble in) | Ethanol |
GHS
Related Laws:
| EC Number | 239-355-3 |
| RTECS# | AB6680000 |
Transport Information:
| HS Number | 2941400000 |
Application
Thiamphenicol: A More Potent and Less Toxic Derivative of Chloramphenicol [C2255]
Thiamphenicol was a semi-synthetic chloramphenicol at first in which the nitro moiety of chloramphenicol [C2255] was replaced by a methylsulphone. Thiamphenicol can now be made by total chemical synthesis. Thiamphenicol has broad activity against Gram-positive and Gram-negative aerobes and for some anaerobes. Thiamphenicol has a similar spectrum of activity to that of chloramphenicol, but is more potent and less toxic. Thiamphenicol inhibits protein synthesis in susceptible organisms by binding to specific nucleotides in 23S rRNA within the 50S subunit of a bacterial ribosome.
References
- Chloramphenicol: relation of structure to activity and toxicity (a review)
- A comparative study on the inhibitory actions of chloramphenicol, thiamphenicol and some fluorinated derivatives
- Effects of chloramphenicol, florfenicol, and thiamphenicol on growth of algae Chlorella pyrenoidosa, Isochrysis galbana, and Tetraselmis chui
- Simultaneous determination and confirmation of chloramphenicol, thiamphenicol, florfenicol and florfenicol amine in chicken muscle by liquid chromatography-tandem mass spectrometry
- A critical review of screening methods for the detection of chloramphenicol, thiamphenicol, and florfenicol residues in foodstuffs
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