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Published TCIMAIL newest issue No.197
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CAS RN: 97240-79-4 | Product Number: T2755
Topiramate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2,3:4,5-Di-O-isopropylidene-1-O-sulfamoyl-β-D-fructopyranose
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 1G |
€41.00
|
6 | ≥40 |
| 5G |
€158.00
|
Contact Us | 8 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T2755 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__2H__2__1NO__8S = 339.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 97240-79-4 |
| Reaxys Registry Number | 5988957 |
| PubChem Substance ID | 125307929 |
| Merck Index (14) | 9547 |
| MDL Number | MFCD00865320 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 124.0 to 128.0 °C |
| Specific rotation [a]20/D | -29.0 to -33.0 deg(C=1, MeOH) |
Properties (reference)
| Melting Point | 126 °C |
| Specific Rotation | -31° (C=1,MeOH) |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | LS7083000 |
Transport Information:
| HS Number | 2932990090 |
Application
Mechanisms of Action and Preclinical Evaluation of Topiramate
References
- Topiramate: Preclinical evaluation of a structurally novel anticonvulsant
- Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold
- Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells
- Inhibition of transient and persistent Na+ current fractions by the new anticonvulsant topiramate
- S. Taverna, G. Sancini, M. Mantegazza, S. Franceschetti, G. Avanzini, J. Pharmacol. Exp. Ther. 1999, 288, 960.
- Two new actions of topiramate: inhibition of depolarizing GABAA-mediated responses and activation of a potassium conductance
- Novel Mechanisms of Action of Three Antiepileptic Drugs, Vigabatrin, Tiagabine, and Topiramate
PubMed Literature
Articles/Brochures
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