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Published TCIMAIL newest issue No.197
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CAS RN: 133865-89-1 | Product Number: S0935
Safinamide
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Purity: >98.0%(HPLC)
Synonyms:
- (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propionamide
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 100MG |
€99.00
|
1 | 3 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | S0935 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__9FN__2O__2 = 302.35 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 133865-89-1 |
| Reaxys Registry Number | 7142233 |
| PubChem Substance ID | 253662371 |
| Merck Index (14) | 8315 |
| MDL Number | MFCD00897036 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 8.70 to 9.70 % |
| Specific rotation [a]20/D | +15.0 to +19.0 deg(C=1, AcOH(95vol%)) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 212 °C |
| Specific Rotation | 17° (C=1,95% CH3COOH) |
GHS
Related Laws:
| RTECS# | TX1457385 |
Transport Information:
| HS Number | 2924297099 |
Application
Safinamide: A Na, K Channel Modulator and Monoamine Oxidase B (MAOB) Inhibitor
Safinamide is a sodium and calcium channel modulator, and also inhibits monoamine oxidase B (MAOB) which is an enzyme that catalyzes the oxidation of monoamines. Safinamide is used for the treatment of epilepsy and Parkinson's disease (PD). (The product is for research purpose only.)
References
- Pharmacokinetics and pharmacodynamics of safinamide, a neuroprotectant with antiparkinsonian and anticonvulsant activity
- Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs
- Safinamide (a review)
- Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions (a review)
- Safinamide in the treatment of Parkinson's disease (a review)
PubMed Literature
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