Published TCIMAIL newest issue No.197
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 219580-11-7 | Product Number: P2474
PD 173074
×
![]()
×
Purity: >95.0%(HPLC)
Synonyms:
- 1-(tert-Butyl)-3-[7-[[4-(diethylamino)butyl]amino]-3-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-2-yl]urea
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 10MG |
€50.00
|
Contact Us | 8 |
| 50MG |
€159.00
|
Contact Us | 13 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P2474 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__8H__4__1N__7O__3 = 523.68 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 219580-11-7 |
| Reaxys Registry Number | 10130688 |
| PubChem Substance ID | 354335228 |
| MDL Number | MFCD08705327 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
Properties (reference)
| Melting Point | 86 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2933998090 |
Application
Research on regenerative medicine
PD 173074 inhibits the differentiation of mouse and human embryo stem cells1,2) and human induced pluripotent stem cells.3)
References
- 1) The ground state of embryonic stem cell self-renewal
- 2) Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs
- 3) Virus-free induction of pluripotency and subsequent excision of reprogramming factors
Application
PD173074: A Selective VEGFR and FGFR Inhibitor
PD173074 is a selective vascular endothelial growth factor receptor (VEGFR) inhibitor, and also a selective fibroblast growth factor receptor (FGFR) inhibitor. VEGF is a signalling protein that induces angiogenesis and endothelial cell proliferation and it plays an important role in regulating vasculogenesis. FGF is a carrier protein that regulates important biological processes including cell proliferation and differentiation during development and tissue repair. The human FGFR reportedly comprises of four family members, FGFR1, FGFR2, FGFR3 and FGFR4. Recently, the anti-tumor activities of PD173074, targeted neoangiogenesis and mitogenesis, have been reported. (The product is for research purpose only.)
References
- Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain
- Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma
- Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074
- Cancer genomics and genetics of FGFR2 (Review)
- The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer Growth in vitro and in vivo
PubMed Literature
Articles/Brochures
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.