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CAS RN: 58-39-9 | Product Number: P1970
Perphenazine
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Purity: >97.0%(T)(HPLC)
Synonyms:
- 2-Chloro-10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazine
- 4-[3-(2-Chlorophenothiazin-10-yl)propyl]-1-piperazineethanol
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 5G |
84,00 €
|
2 | 17 |
| 25G |
290,00 €
|
1 | 7 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P1970 |
| Purity / Analysis Method | >97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__6ClN__3OS = 403.97 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 58-39-9 |
| Reaxys Registry Number | 54730 |
| PubChem Substance ID | 253660321 |
| Merck Index (14) | 7183 |
| MDL Number | MFCD00056798 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 95.0 to 99.0 °C |
Properties (reference)
| Melting Point | 97 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | 28.3 mg/l 24 °C |
| Solubility (soluble in) | Acetone, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 200-381-5 |
| RTECS# | TL7175000 |
Transport Information:
| HS Number | 2933998090 |
Application
Perphenazine: A Classical Phenothiazine Typical Antipsychotic
Perphenazine is a classical phenothiazine typical antipsychotic with a potency similar to haloperidol [H0912], a dopamine antagonist. It is extensively metabolized in the liver to a number of metabolites. The pharmacokinetics of perphenazine is mediated by cytochrome P450 2D6 (CYP2D6) and thus is subject to genetic polymorphism. It induces cleft palate in mice fetuses. (The product is for research purpose only.)
References
- Perphenazine (Trilafon) Metabolism in Psychotic Patients
- Steady-state serum concentrations of the neuroleptic perphenazine in relation to CYP2D6 genetic polymorphism
- Pharmacogenetics of classical and new antipsychotic drugs
- Reduction of Drug-Induced Cleft Palate in Mice
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