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Published TCIMAIL newest issue No.197
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CAS RN: 481-42-5 | Product Number: P1139
Plumbagin
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 5-Hydroxy-2-methyl-1,4-naphthoquinone
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 1G |
156,00 €
|
4 | ≥100 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P1139 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__1H__8O__3 = 188.18 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 481-42-5 |
| Reaxys Registry Number | 1870475 |
| PubChem Substance ID | 87575243 |
| Merck Index (14) | 7538 |
| MDL Number | MFCD00001682 |
Specifications
| Appearance | Orange to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 75.0 to 79.0 °C |
| Solubility in hot Methanol | very faint turbidity |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 77 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H314 : Causes severe skin burns and eye damage. |
| Precautionary Statements | P260 : Do not breathe dust. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
Related Laws:
| EC Number | 207-569-6 |
| RTECS# | QL8500000 |
Transport Information:
| UN Number | UN2923 |
| Class | 8 / 6.1 |
| Packing Group | III |
| HS Number | 2914698090 |
Application
Efflux pump inhibitor
In vitro analysis revealed the ability of plumbagin to increase susceptibility to several antibiotics through the inhibition of AcrB-mediated substrate efflux.1)
References
- 1) Phytochemicals increase the antibacterial activity of antibiotics by acting on a drug efflux pump
Application
Plumbagin: A Plant Secondary Metabolite with Many Biological Activities
Plumbagin is one of the plant secondary metabolite of three major phylogenic families, Plumbaginaceae, Droseraceae, and Ebenaceae. Pharmacological studies indicate that plumbagin exhibits many biological activities, such as antitumor, antibacterial, antifungal, anti-inflammatory and antioxidant activities. (The product is for research purpose only.)
References
- Perspectives on medicinal properties of plumbagin and its analogs (a review)
- Anticancer Properties and Pharmaceutical Applications of Plumbagin: A Review
- Determination of plumbagin by normal-phase high-performance liquid chromatography
- High-performance liquid chromatography for quantification of plumbagin, an anti-Helicobacter pylori compound of Plumbago zeylanica L.
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