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CAS RN: 152520-56-4 | Product Number: N0954
Nebivolol Hydrochloride
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 20MG |
€82.00
|
1 | 15 |
| 100MG |
€288.00
|
1 | 12 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | N0954 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__5F__2NO__4·HCl = 441.90 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 20MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 152520-56-4 |
| Related CAS RN | 118457-14-0 |
| PubChem Substance ID | 253661900 |
| Merck Index (14) | 6432 |
| MDL Number | MFCD07357273 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 223.0 to 228.0 °C |
Properties (reference)
| Melting Point | 226 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
Transport Information:
| HS Number | 2932990090 |
Application
β1-アドレナリン受容体選択的アンタゴニスト作用と一酸化窒素 (NO) の遊離を介する薬理作用を併せ持つ化合物，ネビボロール塩酸塩
Nebivolol hydrochloride is a third-generation β-adrenergic receptor antagonist (β-blocker). It differs from other β-adrenergic receptor antagonists (propranolol hydrochloride [P0995], carvedilol [C2260], bisoprolol hemifumarate [B3994] and atenolol [A1414]) as it combines highly selective β1-adrenergic receptor antagonist properties with nitric oxide-mediated vasodilatory actions and beneficial effects on endothelial function. (The product is for research purpose only.)
References
- Pharmacological and hemodynamic profile of nebivolol, a chemically novel, potent, and selective β1-adrenergic antagonist
- Nebivolol: a third-generation β-blocker that augments vascular nitric oxide release: endothelial β2-adrenergic receptor-mediated nitric oxide production
- Third-generation β-blockers stimulate nitric oxide release from endothelial cells through ATP efflux
- Pharmacological mechanisms of clinically favorable properties of a selective β1-adrenoceptor antagonist, nebivolol (a review)
- Nebivolol: a highly selective β1-adrenergic receptor blocker that causes vasodilation by increasing nitric oxide (a review)
- RP-HPLC and HPTLC methods for the estimation of nebivolol hydrochloride in tablet dosage form
- A validated UV spectrophotometric method for estimation of nebivolol hydrochloride in bulk and pharmaceutical formulation
PubMed Literature
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