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Published TCIMAIL newest issue No.197
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CAS RN: 29745-04-8 | Product Number: N0914
Norcantharidin
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Purity: >98.0%(GC)(T)
Synonyms:
- exo-3,6-Epoxyhexahydrophthalic Anhydride
- exo-7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Anhydride
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 1G |
€67.00
|
Contact Us | 2 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | N0914 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__8H__8O__4 = 168.15 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive |
| CAS RN | 29745-04-8 |
| Reaxys Registry Number | 84287 |
| PubChem Substance ID | 253659717 |
| MDL Number | MFCD00213361 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Methanolysis Method) | min. 98.0 % |
| Melting point | 113.0 to 117.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 115 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | RN8400000 |
Transport Information:
| HS Number | 2932190090 |
Application
抗腫瘍・抗転移作用を有するタンパク質ホスファターゼ阻害剤，ノルカンタリジン
Norcantharidin (NCTD) is the demethylated analog of a natural terpene, cantharidin [C0019]. NCTD has more powerful antitumor activity but less cytotoxicity than cantharidin itself. NCTD is a protein phosphatase inhibitor that induces cell cycle arrest and apoptosis, and also blocks tumor metastasis in cancer cells. (The product is for research purpose only.)
References
- Effects of norcantharidin, a protein phosphatase type-2A inhibitor, on the growth of normal and malignant hemopoietic cells
- Effector mechanisms of norcantharidin-induced mitotic arrest and apoptosis in human hepatoma cells
- Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio
- Heterocyclic substituted cantharidin and norcantharidin analogues-synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity
- Small-Molecule Synthetic Compound Norcantharidin Reverses Multi-Drug Resistance by Regulating Sonic Hedgehog Signaling in Human Breast Cancer Cells
- Exploiting protein phosphatase inhibitors based on cantharidin analogues for cancer drug discovery (a review)
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