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CAS RN: 498-95-3 | Product Number: N0420
3-Piperidinecarboxylic Acid
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Purity: >98.0%(T)
Synonyms:
- Nipecotic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 25G |
€49.00
|
1 | 4 |
| 500G |
€446.00
|
1 | 7 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | N0420 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__6H__1__1NO__2 = 129.16 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 498-95-3 |
| Reaxys Registry Number | 81096 |
| PubChem Substance ID | 87573759 |
| SDBS (AIST Spectral DB) | 4623 |
| Merck Index (14) | 6560 |
| MDL Number | MFCD00005992 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Solubility in Water | very faint turbidity |
| NMR | confirm to structure |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 207-873-9 |
| RTECS# | TM6125380 |
Transport Information:
| HS Number | 2933399990 |
Application
γ-アミノ酪酸 (GABA) 再取り込み阻害剤，ニペコチン酸
Nipecotic acid is a γ-aminobutyric acid (GABA) reuptake inhibitor in vitro, used in scientific research. Some nipecotic acid prodrugs have been synthesized and evaluated for their bioactivity in vivo. It is reported that the R-enantiomer [N0654] is a more potent inhibitor than the S-enantiomer [N0678] of the uptake of GABA.
References
- Inhibition of GABA uptake in rat brain slices by nipecotic acid, isoxazoles, and related compounds
- Uptake of γ-aminobutyric acid by a synaptic vesicle fraction isolated from rat brain
- Fast HPLC estimation of γ-aminobutyric acid in microdialysis perfusates: effect of nipecotic and 3-mercaptopropionic acids
- Synthesis, Stability, and Pharmacological Evaluation of Nipecotic Acid Prodrugs
- GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects
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