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CAS RN: 555-57-7 | Product Number: M2618
Pargyline
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Purity: >98.0%(GC)(T)
Synonyms:
- N-Methyl-N-(2-propyn-1-yl)benzylamine
- N-Methyl-N-propargylbenzylamine
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 1G |
€135.00
|
1 | 9 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M2618 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__1__1H__1__3N = 159.23 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 555-57-7 |
| Reaxys Registry Number | 1938132 |
| PubChem Substance ID | 354333810 |
| Merck Index (14) | 7038 |
| MDL Number | MFCD00008576 |
Specifications
| Appearance | Colorless to Light yellow to Light orange clear liquid |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Boiling Point | 90 °C/4 mmHg |
| Flash point | 84 °C |
| Specific Gravity (20/20) | 0.95 |
| Refractive Index | 1.52 |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 209-101-6 |
| RTECS# | DP6475000 |
Transport Information:
| UN Number | UN2810 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2921490090 |
Application
Pargyline: An Irreversible Selective MAO-B Inhibitor.
Monoamine oxidase B (MAO-B) is a mitochondrial outer membrane flavoenzyme, which keeps the norepinephrine concentration in the axoplasm low. Therefore, MAO-B is a well-known target for antidepressant and neuroprotective agents. Pargyline is an irreversible selective MAO-B inhibitor. Pargyline is used to treat moderate to severe hypertension. Currently, pargyline is used as an antiparkinson agent. (The product is for research purpose only.)
References
- The acetylenic monoamine oxidase inhibitors clorgyline, deprenyl, pargyline, and J-508: their properties and applications (a review)
- Metabolism of monoamine oxidase inhibitors (a review)
- Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders
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