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CAS RN: 1082949-68-5 | Product Number: L0463
LY-2584702 Tosylate
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Purity: >95.0%(HPLC)
Synonyms:
- 4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]piperidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine 4-Methylbenzenesulfonate
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 10MG |
€135.00
|
Contact Us | ≥100 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | L0463 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__1__9F__4N__7·C__7H__8O__3S = 617.62 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 1082949-68-5 |
| Reaxys Registry Number | 18671815 |
| MDL Number | MFCD29054739 |
Specifications
| Appearance | White to Yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 93.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
Application
LY-2584702 Tosylate: An Oral, Selective, ATP-Competitive Inhibitor of p70 Ribosomal S6 Kinase
LY-2584702 tosylate is an oral, selective, ATP-competitive inhibitor of p70 ribosomal S6 kinase (P70S6K), a downstream component of the phosphatidylinositol 3-kinase signaling pathway that regulates cell proliferation and survival. It has been reported that LY-2584702 inhibits the phosphorylation of S6 kinase confers in cancer cells and exhibits anti-tumor activity. (The product is for research use only.)
References
- A phase Ib trial of LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or everolimus in patients with solid tumours
- A phase I trial of LY2584702 tosylate, a p70 S6 kinase inhibitor, in patients with advanced solid tumours
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