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CAS RN: 89396-94-1 | Product Number: I0901
Imidapril Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (4S)-3-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic Acid Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 25MG |
€99.00
|
1 | 12 |
| 100MG |
€296.00
|
1 | 18 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | I0901 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__7N__3O__6·HCl = 441.91 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 89396-94-1 |
| Related CAS RN | 89371-37-9 |
| Reaxys Registry Number | 4835331 |
| PubChem Substance ID | 253661853 |
| Merck Index (14) | 4911 |
| MDL Number | MFCD00923828 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -65.0 to -69.0 deg(C=1, MeOH) |
Properties (reference)
| Melting Point | 206 °C(dec.) |
| Specific Rotation | -67° (C=1,MeOH) |
| Solubility in water | Soluble |
| Solubility (slightly sol. in) | Ethanol |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. |
Related Laws:
| RTECS# | NI8927400 |
Transport Information:
| HS Number | 2933299090 |
Application
Imidapril Hydrochloride: A Non-Sulfhydryl Group and Long-Acting ACE Inhibitor
Imidapril hydrochloride is an ethyl ester prodrug of the active metabolite imidaprilat. Imidapril is a long-acting and non-sulfhydryl group drug with fewer side effects angiotensin-converting enzyme (ACE) inhibitor to suppress the conversion of angiotensin I to angiotensin II and thereby reduce total peripheral resistance (TRP) and systemic blood pressure (BP). (The product is for research purpose only.)
References
- Protection of the cardiovascular system by imidapril, a versatile angiotensin-converting enzyme inhibitor (a review)
- Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin-converting enzyme inhibitors. An update (a review)
- Imidapril: a review of its use in essential hypertension, type 1 diabetic nephropathy and chronic heart failure
- Imidapril: will fewer adverse events translate into better long-term outcomes? (a review)
PubMed Literature
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