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CAS RN: 54-92-2 | Product Number: I0893
Iproniazid
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Purity: >96.0%(T)(HPLC)
Synonyms:
- Isonicotinic Acid 2-Isopropylhydrazide
- 1-Isonicotinoyl-2-isopropylhydrazine
Product Documents:
| Size | Unit Price | Belgium | Japan* |
Shipping Information
|
|---|---|---|---|---|
| 200MG |
€29.00
|
1 | 18 | |
| 1G |
€97.00
|
5 | 10 |
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | I0893 |
Purity / Analysis Method 
|
>96.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__3N__3O = 179.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 54-92-2 |
| Reaxys Registry Number | 142700 |
| Merck Index (14) | 5078 |
| MDL Number | MFCD00153819 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Purity(Nonaqueous Titration) | min. 96.0 % |
| Melting point | 109.0 to 114.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 112 °C |
| Solubility in water | Soluble |
| Solubility (soluble in) | Alcohol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 200-218-8 |
| RTECS# | NS1925000 |
Transport Information:
| HS Number | 2933399999 |
Application
Iproniazid: A Monoamine-Oxidase Inhibitor (MAOI)
Iproniazid is a monoamine-oxidase inhibitor (MAOI). Originally, it was intended for the treatment of tuberculosis. In 1952, its antidepressant properties were discovered. MAOIs act by inhibiting the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters. Iproniazid was then used as an antidepressant agent until it was found to cause liver damage in 1961. It is oxidized by cytochrome P-450 enzymes in liver microsomes to a highly toxic agent, isopropylhydrazine. (The product is for research purpose only.)
References
- Monoamine oxidase inhibitors. (a review)
- Isoniazid and iproniazid: activation of metabolites to toxic intermediates in man and rat
- The role of metabolism in the hepatotoxicity of isoniazid and iproniazid (a review)
- Monoaminergic neurotransmission: the history of the discovery of antidepressants from 1950s until today (a review)
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