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CAS RN: 15687-27-1 | Product Number: I0415
Ibuprofen
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Purity: >98.0%(GC)(T)
Synonyms:
- 2-(4-Isobutylphenyl)propionic Acid
- 4-Isobutyl-α-methylphenylacetic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 25G |
57,00 €
|
14 | ≥100 |
| 100G |
154,00 €
|
3 | 20 |
| 500G |
492,00 €
|
2 | 28 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | I0415 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__1__3H__1__8O__2 = 206.29 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 15687-27-1 |
| Reaxys Registry Number | 2049713 |
| PubChem Substance ID | 87571768 |
| SDBS (AIST Spectral DB) | 10570 |
| Merck Index (14) | 4881 |
| MDL Number | MFCD00010393 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 75.0 to 78.0 °C |
| Solubility in Methanol | almost transparency |
Properties (reference)
| Melting Point | 76 °C |
| Boiling Point | 157 °C/4 mmHg |
| Solubility in water | Insoluble |
| Degree of solubility in water | 21 mg/l 25 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| EC Number | 239-784-6 |
| RTECS# | MU6640000 |
Transport Information:
| HS Number | 2916399070 |
Application
Ibuprofen: A Non-Selective Non-Steroidal Anti-Inflammatory Drug (NSAID)
Ibuprofen is a non-selective non-steroidal anti-inflammatory drug (NSAID) in the propionic acid derivatives group, which possesses analgesic and antipyretic activities. Ibuprofen is a racemic compound and the active enantiomer is (S)-(+)-ibuprofen [I0549] which works by inhibiting both the COX-1 and COX-2 enzymes and prostaglandin synthesis. NSAIDs also include ketoprofen [K0038], loxoprofen [L0244] and naproxen [M1021] among others. Resently, some studies have suggested that NSAIDs may reduce the risk of certain types of cancer and Alzheimer's disease. (The product is for research purpose only.)
References
- Ibuprofen: pharmacology, efficacy and safety (a review)
- Enantioselective pharmacokinetics of ibuprofen and involved mechanisms (a review)
- Cyclo-oxygenase-2: pharmacology, physiology, biochemistry and relevance to NSAID therapy (a review)
- Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: A critical review of non-selective COX-2 blockade (a review)
- NSAID and antioxidant prevention of Alzheimer's disease: Lessons from in vitro and animal models (a review)
- Resolution of enantiomers of ibuprofen by liquid chromatography: a review
- Ibuprofen (a review on the methods of preparations, physical properties, stability, metabolism and pharmacokinetics and methods for the detection of ibuprofen)
Application
Binding of Ibuprofen to Human Serum Albumin
Ibuprofen is known to have affinity for Human Serum Albumin (HSA) and to bind (interact) to drug binding site II on HSA. Those were confirmed using our ibuprofen with Surface Plasmon Resonance (SPR) and a method using fluorescent probes. 【SPR】Dose responses of ibuprofen to HSA were confirmed by SPR. Biacore, as a SPR biosensor, was used for the assay, according to the user’s guide of the instrument.
＜Assay condition＞ Sensor Chip: Series S Sensor Chip CM5, Immobilization: HAS (Amine Coupling method), Buffer : 5%DMSO in PBS. ＜Result＞ “Square wave” sensorgrams were exhibited at each concentration, and concentration dependent binding of ibuprofen to HSA was confirmed. 【Method using fluorescent probes】The drug biding site of ibuprofen was confirmed using fluorescent probes which bind to drug binding site on HSA. Dansylamide (DNSA) [D5405] was used as fluorescent probe for site I, and dansylglycine (DNSG) [D5406], BD140 [D4898] were used as fluorescent probes for site II, and then bindings to site I and site II were confirmed.
＜Assay condition＞ Buffer: 1 % DMSO in phosphate buffer (pH 7.2 - 7.5); HSA: 5 µM (DNSA), 20 µM (DNSG, BD140) (50 µL/well) (Fatty acid free HSA is recommended.); Ibuprofen: each concentration (50 µL/well); DNSA: 80 µM, DNSG: 20 µM, BD140: 20 µM (50 µL/well); Incubation: 20-25 °C for 30 min; Measurement: plate-reader with excitation = 365 nm and emission = 480 nm (DNSA, DNSG), with excitation = 365 nm and emission = 585 nm (BD140). ＜Result＞ As shown in upper diagram, inhibition against binding of dansylglycine and BD140 which are fluorescent probes for site II by ibuprofen was confirmed. And also, little or extremely weak inhibition against binding of dansylamide which is fluorescent probe for site I was confirmed. In these ways, our ibuprofen can be used for study of interaction with HSA. Also, DNSA [D5405], DNSG [D5406] and BD140 [D4898] can be used for study of drug binding site on HSA.
References
- Fluorescent Dye Cocktail for Multiplex Drug￢Site Mapping on Human Serum Albumin
- High-resolution and high-throughput protocols for measuring drug/human serum albumin interactions using BIACORE
- Biosensor Analysis of the Interaction between Immobilized Human Serum Albumin and Drug Compounds for Prediction of Human Serum Albumin Binding Levels
- Characterizing a drug's primary binding site on albumin
- Structural basis of the drug-binding specificity of human serum albumin
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