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CAS RN: 19235-17-7 | Product Number: H1863
5-(Hydroxymethyl)cytidine
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Purity: >95.0%(HPLC)
Synonyms:
- 5-Hydroxymethylcytidine
- 4-Amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-(hydroxymethyl)pyrimidin-2(1H)-one
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 50MG |
€195.00
|
Contact Us | 17 |
| 200MG |
€620.00
|
Contact Us | 33 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | H1863 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__5N__3O__6 = 273.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 19235-17-7 |
| Reaxys Registry Number | 553746 |
| MDL Number | MFCD26523159 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 214.0 to 218.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 216 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2934999090 |
Application
5-(Hydroxymethyl)cytidine: An Important Base-modified Ribonucleoside in Epigenetics
5-(Hydroxymethyl)cytidine (hm5C) is a modified ribonucleoside that has long been known to be present in mRNA, tRNA, and rRNA. 5-(Hydroxymethyl)cytidine in RNA is generated by 5-methylcytidine (m5C) [M1931] oxidation in vivo. Recent studies have discovered that 5-(hydroxymethyl)cytidine is a prevalent mRNA modification in eukaryotes and has roles in cell viability and development through these effects on RNA as follows; RNA structure and translation efficiency.1,2) In addition, 5-(hydroxymethyl)cytidine has been reported to have important functions in the nervous system.3-5)
References
- 1) Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
- 2) Formation and Abundance of 5-Hydroxymethylcytosine in RNA
- 3) Transcriptome-wide distribution and function of RNA hydroxymethylcytosine
- 4) Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients
- 5) Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain
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