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Published TCIMAIL newest issue No.197
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CAS RN: 178306-52-0 | Product Number: H1568
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 1G |
94,00 €
|
1 | 4 |
| 5G |
327,00 €
|
1 | 3 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | H1568 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__6O__4 = 272.30 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 178306-52-0 |
| Reaxys Registry Number | 8413483 |
| PubChem Substance ID | 354334235 |
| MDL Number | MFCD11113284 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | +11.0 to +15.0 deg(C=1.8, EtOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 120 °C(dec.) |
| Specific Rotation | 13° (C=1.8,EtOH) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2918999090 |
Application
A Key Synthetic Intermediate of Ambrisentan
This product is a key synthetic intermediate of ambrisentan [A2966] which is a highly selective Endothelin-A (ETA) receptor antagonist used for the treatment of pulmonary arterial hypertension (PAH).
References
- Multistep process for preparation of ambrisentan and darusentan
- R. M. Satyanarayana, C. Nagaraju, A. K. Ramprasad, WO/2010/070658.
- Process for preparation of ambrisentan from (S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid and a 4,6-dimethylpyrimidine derivative
- R. M. Gidwani, C. Janssen, A. Mathieu, W. Albrecht, F. Lehmamnn, WO/2010/091877.
- Rapid determination of ambrisentan enantiomers by enantioselective liquid chromatography using cellulose-based chiral stationary phase in reverse phase mode
- LC-MS/MS characterization of forced degradation products of ambrisentan: development and validation of a stability-indicating RP-HPLC method
Application
A Synthetic Intermediate of Endothelin Receptor Antagonists
This reagent is used for synthesis of endothelin receptor antagonists, such as darusentan [CAS: 171714-84-4].
References
- Discovery and Synthesis of (S)-3-[2-(3,4-Dimethoxyphenyl)ethoxy]-2- (4,6-dimethylpyrimidin-2-yloxy)-3,3-diphenylpropionic Acid (LU 302872), a Novel Orally Active Mixed ETA/ETB Receptor Antagonist
- Structural Similarity and Its Surprises: Endothelin Receptor Antagonists - Process Research and Development Report
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