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Published TCIMAIL newest issue No.197
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CAS RN: 65646-68-6 | Product Number: H1464
all-trans-N-(4-Hydroxyphenyl)retinamide
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Purity: >98.0%(HPLC)
Synonyms:
- 4-HPR
- Fenretinide
- Retinoic Acid p-Hydroxyanilide
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 10MG |
€41.00
|
Contact Us | 6 |
| 100MG |
€254.00
|
1 | 4 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | H1464 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__6H__3__3NO__2 = 391.56 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 65646-68-6 |
| Reaxys Registry Number | 5769490 |
| PubChem Substance ID | 253662215 |
| Merck Index (14) | 3998 |
| MDL Number | MFCD00792674 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 170.0 to 174.0 °C |
Properties (reference)
| Melting Point | 172 °C |
| Maximum Absorption Wavelength | 362(MeOH) nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. |
| Precautionary Statements | P261 : Avoid breathing dust. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
| RTECS# | VH6420000 |
Transport Information:
| HS Number | 2924297099 |
Application
4-HPR: A Retinoid Analog with Antitumor Activities
all-trans-N-(4-hydroxyphenyl)-retinamide (4-HPR) is a synthetic retinoid analog that not only inhibits the proliferation of cancer cells but also can induces apoptosis in certain cancer cells. Recent studies have shown that 4-HPR has additional properties including the prevention of high-fat diet-induced obesity and insulin resistance. The mechanism of action of 4-HPR is still not fully understood.
References
- N-(4-Hydroxyphenyl)retinamide induces apoptosis of malignant hemopoietic cell lines including those unresponsive to retinoic acid
- Bioactivities of N-(4-hydroxyphenyl) retinamide and retinoyl β-glucuronide (a review)
- Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)retinamide in neuroblastoma cell lines
- Mechanisms of fenretinide-induced apoptosis (a review)
- The mechanisms of Fenretinide-mediated anti-cancer activity and prevention of obesity and type-2 diabetes (a review)
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