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Published TCIMAIL newest issue No.197
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CAS RN: 278779-30-9 | Product Number: G0648
GW 4064
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- 3-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy]styryl]benzoic Acid
- 3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropyl-1,2-oxazol-4-yl]methoxy]phenyl]vinyl]benzoic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 10MG |
120,00 €
|
Contact Us | 8 |
| 50MG |
355,00 €
|
Contact Us | 8 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | G0648 |
| Purity / Analysis Method | >95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__8H__2__2Cl__3NO__4 = 542.84 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 278779-30-9 |
| Reaxys Registry Number | 10125635 |
| MDL Number | MFCD09971006 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| Melting point | 173.0 to 177.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 175 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
Transport Information:
| HS Number | 2934999090 |
Application
GW 6064: The First Non-Steroidal and Selective Farnesoid X Receptor (FXR) Agonist
The farnesoid X receptor (FXR) is a bile acid-activated nuclear receptor (BAR) expressed primarily in the liver and intestine.1) FXR plays important roles not only in bile acid, lipid metabolism, and carbohydrate homeostasis, but also in inflammatory responses.2) GW 6064 is the first non-steroidal and selective FXR agonist with decent submicromolar potency and has been used to study the role of FXR in dyslipidemia, diabetes, obesity and cancer.2,3) (The product is for research purpose only.)
References
- 1) Liver X Receptor and Farnesoid X Receptor as Therapeutic Targets
- 2) Role of farnesoid X receptor in inflammation and resolution (a review)
- 3) Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR
Product Documents (Note: Some products will not have analytical charts available.)
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