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CAS RN: 24169-02-6 | Product Number: E0957
Econazole Nitrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-[2-(4-Chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole Nitrate
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 5G |
€52.00
|
Contact Us | ≥80 |
| 25G |
€168.00
|
1 | 37 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | E0957 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__1__5Cl__3N__2O·HNO__3 = 444.69 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 24169-02-6 |
| Related CAS RN | 27220-47-9 |
| Reaxys Registry Number | 4836249 |
| PubChem Substance ID | 253660301 |
| Merck Index (14) | 3502 |
| MDL Number | MFCD00058160 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 161 °C(dec.) |
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Ethanol |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 246-053-5 |
| RTECS# | NI4450000 |
Transport Information:
| HS Number | 2933299090 |
Application
Econazole Nitrate: An Imidazole Antifungal Reagent with other Activities.
Econazole nitrate is an imidazole antifungal reagent which is very closely related structurally to another imidazole derivative, miconazole nitrate [M1769]. It has broad-spectrum antimycotic activity. In addition, it is reported as a blocker of Ca2+ influx, and an inhibitor of steroid aromatization. Recently, various drug delivery systems have been reported to enhance the drug antifungal activity.
References
- Econazole: a review of its antifungal activity and therapeutic efficacy
- Econazole Nitrate (description, synthesis, physical properties, stability and degradation products)
- Inhibition of calcium transport pathways in thymic lymphocyte by econazole, miconazole, and SKF 96365
- Imidazole antimycotics: selective inhibitors of steroid aromatization and progesterone hydroxylation
- Nanosized ethanolic vesicles loaded with econazole nitrate for the treatment of deep fungal infections through topical gel formulation
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