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Published TCIMAIL newest issue No.197
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CAS RN: 305-01-1 | Product Number: E0386
Esculetin
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 6,7-Dihydroxycoumarin
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 1G |
€43.00
|
1 | ≥60 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | E0386 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__6O__4 = 178.14 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 305-01-1 |
| Reaxys Registry Number | 152788 |
| PubChem Substance ID | 87569645 |
| SDBS (AIST Spectral DB) | 23227 |
| Merck Index (14) | 3697 |
| MDL Number | MFCD00006874 |
Specifications
| Appearance | Light yellow to Brown to Dark green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 273 °C |
| Maximum Absorption Wavelength | 344(MeOH) nm |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 206-161-5 |
| RTECS# | GN6382500 |
Transport Information:
| HS Number | 2932209090 |
Application
Quorum sensing research / Biofilm research
References
- Inhibition of Quorum Sensing and Biofilm Formation of Esculetin on Aeromonas Hydrophila
- New Insights into the Antibacterial Activity of Hydroxycoumarins against Ralstonia solanacearum
- Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa
Application
Esculetin: The Main Active Ingredient of the Traditional Chinese Medicine Cortex Fraxini
Esculetin is the main active ingredient of the traditional Chinese medicine Cortex Fraxini with antioxidant properties. Esculetin has shown its various pharmacological effects, including anti-inflammatory, anticoagulant, antioxidant, liver-protective, antidiabetic, antibacterial and antitumor effects. Some reports suggests that esculetin exerts inhibitory effect on lipoxygenase and cell cycle, but the mechanisms of its action are not completely understood. (The product is for research purpose only.)
References
- Inhibitory effect of esculetin on 5-lipoxygenase and leukotriene biosynthesis
- Inhibition of cell cycle progression in human leukemia HL-60 cells by esculetin
- Inhibitory effect of esculetin on oxidative damage induced by t-butyl hydroperoxide in rat liver
- Studies on coumarins and coumarin-related compounds to determine their therapeutic role in the treatment of cancer (a review)
- Pharmacological Activities and Synthesis of Esculetin and Its Derivatives: A Mini-Review
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
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Other Documents
Related Products
![Esculetin [Matrix for MALDI-TOF/MS]](/medias/E1287.jpg?context=bWFzdGVyfHJvb3R8MzI5MTJ8aW1hZ2UvanBlZ3xhR05tTDJnek1TODRPVE13TlRnMU5qY3pOelU0TDBVeE1qZzNMbXB3Wnd8Y2ExOWNlMTcwZjRhMDJlZmU5NTU3YzM0ZDIxMzNkZmE5ZjZiZWNjMDVmNzY3YjdlZDdlYzE1Y2Y5MzFhN2U4Mg "Esculetin [Matrix for MALDI-TOF/MS]")
Esculetin [Matrix for MALDI-TOF/MS]
| Product # | E1287 |
| CAS RN | 305-01-1 |
| Purity / Analysis Method: | >99.0%(T)(HPLC) |