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CAS RN: 258516-84-6 | Product Number: D5828
Dibenzyl (Chloromethyl) Phosphate
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Purity: >95.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 1G |
365,00 €
|
Contact Us | 22 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D5828 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__6ClO__4P = 326.71 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 258516-84-6 |
| Reaxys Registry Number | 9131198 |
| PubChem Substance ID | 468591588 |
| MDL Number | MFCD06652586 |
Specifications
| Appearance | Colorless to Light orange to Yellow clear liquid |
| Purity(HPLC) | min. 95.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Flash point | 346 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2919900090 |
Application
TCI Practical Example: Addition of Phosphoric Ester Group to a Phenol Derivative
Used Chemicals
Procedure
To a reaction vessel were added 2,6-diisopropylphenol (0.42 g, 2.36 mmol) and DMF (20 mL) under nitrogen atmosphere, cooling with an ice bath. Sodium hydride (60%, dispersed in liquid paraffin) (0.113 g, 2.83 mmol) was added and stirred for 30 min, then (chloromethyl)dibenzyl phosphate (1.0 g, 3.06 mmol) was added. The mixture was stirred for 2 h at room temperature and cooled with an ice bath. Water (20 mL) was added and extracted with diethyl ether. The organic layer was sequentially washed with water and brine, dried over magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (hexane:ethyl acetate = 5:1) to give 1 (0.8 g, 72% yield) as a colorless liquid.
Experimenter’s Comments
The reaction mixture was monitored by TLC (hexane:ethyl acetate = 5:1, Rf = 0.3).
Analytical Data（Compound 1）
1H NMR (400 MHz, CDCl3); δ 7.38-7.27 (m, 10H), 7.17-7.09 (m, 3H), 5.42 (d, 2H, J = 9.6 Hz), 5.06-4.95 (m, 4H), 3.33(sep, 2H, J = 6.9 Hz), 1.18 (d, 12H, J = 6.9 Hz).
Lead Reference
- Synthesis and evaluation of prodrugs of corticotropin-releasing factor-1 (CRF1) receptor antagonist BMS-665053 leading to improved oral bioavailability
Lead Reference
- Synthesis and Characterization of a Phosphate Prodrug of Isoliquiritigenin
Articles/Brochures
TCIMAIL
[Product Highlights] Alkylating Reagents Containing Phosphoric Ester Groups for Prodrug DesignProduct Documents (Note: Some products will not have analytical charts available.)
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