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Published TCIMAIL newest issue No.197
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CAS RN: 151103-08-1 | Product Number: D4505
4-(Difluoromethoxy)-3-hydroxybenzaldehyde
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Purity: >98.0%(GC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 5G |
€156.00
|
1 | 11 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D4505 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__8H__6F__2O__3 = 188.13 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 151103-08-1 |
| Reaxys Registry Number | 9120886 |
| PubChem Substance ID | 468591269 |
| MDL Number | MFCD04406687 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 88.0 to 92.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 90 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2913000020 |
Application
A Synthetic Intermediate of Phosphodiesterase-4 (PDE4) Inhibitors
This product is used for the synthesis of phosphodiesterase-4 (PDE4) inhibitors, such as roflumilast [R0193] used for the treatment of chronic obstructive pulmonary disease (COPD).
References
- Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors
- Novel Roflumilast analogs as soft PDE4 inhibitors
- Development and validation of stability-indicating HPLC method for roflumilast and related substances
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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