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CAS RN: 133627-46-0 | Product Number: C3241
2-Chloro-N-(2-chloro-4-methyl-3-pyridyl)nicotinamide
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Purity: >98.0%(GC)
Synonyms:
- 2-Chloro-N-(2-chloro-4-methylpyridin-3-yl)pyridine-3-carboxamide
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 5G |
€82.00
|
1 | 4 |
| 25G |
€262.00
|
1 | 28 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C3241 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__2H__9Cl__2N__3O = 282.12 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 133627-46-0 |
| Reaxys Registry Number | 47533738 |
| PubChem Substance ID | 354334354 |
| MDL Number | MFCD09031256 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 193.0 to 197.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 195 °C |
| Solubility (soluble in) | Dimethylformamide |
GHS
Related Laws:
Transport Information:
| HS Number | 2933399990 |
Application
A Synthetic Intermediate of Nevirapine, a Non-Nucleoside Reverse Transcriptase Inhibitor
This product has been used as a synthetic intermediate of nevirapine [N0922] which is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that active against HIV-1.
References
- Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones
- Novel Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase. 3. Dipyrido[2,3-b:2',3'-e]diazepinones
- Efficient synthesis of nevirapine analogs to study its metabolic profile by click fishing
- Validation of a high-performance liquid chromatography method for the assay of and determination of related organic impurities in nevirapine drug substance
Application
The Synthetic Intermediate of Nevirapine
C3241 is the synthetic intermediate of nevirapine [N0922] which is a non-nucleoside inhibitor of HIV-1 reverse transcriptase.
References
- Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones
- Novel Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase. 3. Dipyrido[2,3-b:2',3'-e]diazepinones
- Validation of a high-performance liquid chromatography method for the assay of and determination of related organic impurities in nevirapine drug substance
PubMed Literature
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