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CAS RN: 23593-75-1 | Product Number: C2867
Clotrimazole
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-(2-Chlorotrityl)imidazole
- 1-[(2-Chlorophenyl)diphenylmethyl]imidazole
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 5G |
€27.00
|
3 | ≥80 |
| 25G |
€97.00
|
1 | 2 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C2867 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__1__7ClN__2 = 344.84 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 23593-75-1 |
| Reaxys Registry Number | 622318 |
| PubChem Substance ID | 253661533 |
| Merck Index (14) | 2417 |
| MDL Number | MFCD00057220 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 144.0 to 148.0 °C |
Properties (reference)
| Melting Point | 147 °C |
| Maximum Absorption Wavelength | 556(Phosphate buffer sol.) nm |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Methanol, Ethanol, Dimethylformamide |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. |
Related Laws:
| EC Number | 245-764-8 |
| RTECS# | NI4377000 |
Transport Information:
| HS Number | 2933299090 |
Application
Clotrimazole: A Synthetic Imidazole Antifungal and an IKCA Inhibitor
Clotrimazole is a chemical synthetic imidazole antifungal. It has in vitro strong activity against Candida species, Trichophyton species, Microsporum species and Malassezia furfur. Besides that, clotrimazole has some in vitro activity against certain Gram-positive bacteria. Clotrimazole works to kill individual Candida or fungal cells by altering the permeability of the fungal cell wall. In additon, clotrimazole shows therapeutic effects on sickle cell disease, and etc. by inhibiting membrane intermediate-conductance Ca2+-activated K+ channels (IKCa). (The product is for research purpose only.)
References
- Clotrimazole. Review of its antifungal activity and therapeutic efficacy
- Clotrimazole (a review of its description, properties, synthesis, stability, metabolites, pharmacokinetics, and analysis)
- Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant
- Clotrimazole inhibits cell proliferation in vitro and in vivo
- The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances: demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera
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