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Published TCIMAIL newest issue No.197
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CAS RN: 83881-52-1 | Product Number: C2316
Cetirizine Dihydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 5G |
€100.00
|
2 | 28 |
| 25G |
€322.00
|
Contact Us | 16 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C2316 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__5ClN__2O__3·2HCl = 461.81 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 83881-52-1 |
| Related CAS RN | 83881-51-0 |
| Reaxys Registry Number | 9100316 |
| PubChem Substance ID | 87560950 |
| SDBS (AIST Spectral DB) | 52376 |
| Merck Index (14) | 2022 |
| MDL Number | MFCD00941428 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 225 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | AG0980000 |
Transport Information:
| HS Number | 2933599590 |
Application
Cetirizine dihydrochloride: A Second-Generation Histamine H1-Receptor Antagonist
Cetirizine dihydrochloride is a second-generation histamine H1-receptor antagonist with a long duration of activity and low potential for interaction with drugs metabolised by the hepatic cytochrome P450 system. The active R-enantiomer of cetirizine is levocetirizine [L0264].
References
- Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines
- Molecular Properties and Pharmacokinetic Behavior of Cetirizine, a Zwitterionic H1-Receptor Antagonist
- Binding characteristics of cetirizine and levocetirizine to human H1 histamine receptors: contribution of Lys191 and Thr194
- Cetirizine: a review of its use in allergic disorders (a review)
- Physicochemical, pharmacological and pharmacokinetic properties of the zwitterionic antihistamines cetirizine and levocetirizine (a review)
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