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Published TCIMAIL newest issue No.197
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CAS RN: 22059-22-9 | Product Number: A2646
Acetamidoxime
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Purity: >97.0%(GC)(T)
Synonyms:
- Acetamide Oxime
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 5G |
€53.00
|
1 | 9 |
| 25G |
€178.00
|
6 | 31 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A2646 |
| Purity / Analysis Method | >97.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__2H__6N__2O = 74.08 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 22059-22-9 |
| Reaxys Registry Number | 8829065 |
| PubChem Substance ID | 253660036 |
| MDL Number | MFCD00603514 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 97.0 % |
| Purity(Nonaqueous Titration) | min. 97.0 % |
Properties (reference)
| Melting Point | 138 °C |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
| RTECS# | AC6900000 |
Transport Information:
| HS Number | 2928009090 |
Application
Acetamidoxime: A Useful Reagent for Constructing Heterocyclic Compounds
Experimental procedure1): To a solution of Boc-L-cystine (248.0 g, 0.56 mol), acetamidoxime (89.0 g, 1.20 mol), and 2-Hydroxypyridine N-Oxide (2.9 g, 0.026 mol) in THF (1 L) is added a solution of DCC (250 g, 1.21 mol) in THF (0.8 L) at 0 °C. The mixture is stirred for 16 h while the temperature is allowed to warm to 20 °C. The mixture is cooled to 0 °C and the precipitate is removed by filtration. The filtrate is concentrated in vacuo to a volume of about 0.5 L and then diluted with EtOAc (0.8 L). Upon the addition of H2O (1 L), a precipitate forms which is isolated by filtration to give Boc-L-cystine bis(acetamidoxime) ester (2, 246.6 g) as white crystals. This material is taken up in toluene (0.8 L) and the mixture is heated at reflux for 3 h, the water formed being removed by a Dean-Stark trap. Addition of hexane (3 L) to the cooled mixture leads to crystallization of 3 (215.0 g, 79%) as white crystals.
References
- 1)New Antibacterial Agents Derived from the DNA Gyrase Inhibitor Cyclothialidine
- 2)New linezolid-like 1,2,4-oxadiazoles active against Gram-positive multiresistant pathogens
PubMed Literature
Articles/Brochures
TCIMAIL
[Product Highlights] Acetamidoxime: A Useful Reagent for Constructing Heterocyclic CompoundsProduct Documents (Note: Some products will not have analytical charts available.)
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