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Published TCIMAIL newest issue No.197
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CAS RN: 22252-43-3 | Product Number: A2075
7-Aminodesacetoxycephalosporanic Acid
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Purity: >98.0%(HPLC)
Synonyms:
- 7-ADCA
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 5G |
€43.00
|
Contact Us | 20 |
| 25G |
€138.00
|
Contact Us | 8 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A2075 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__8H__1__0N__2O__3S = 214.24 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 22252-43-3 |
| Reaxys Registry Number | 615092 |
| PubChem Substance ID | 87560170 |
| SDBS (AIST Spectral DB) | 52116 |
| MDL Number | MFCD00151456 |
Specifications
| Appearance | White to Orange to Green powder to crystalline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Specific rotation [a]20/D | +100.0 to +107.0 deg(C=1, 1mol/L HCl) |
Properties (reference)
| Melting Point | 242 °C(dec.) |
| Specific Rotation | 104° (C=1,1mol/L HCl) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| Precautionary Statements | P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P280 : Wear protective gloves. P284 : Wear respiratory protection. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 244-870-1 |
Transport Information:
| HS Number | 2941900000 |
Application
7-Aminodesacetoxycephalosporanic Acid (7-ADCA): A Starting Compound for Semisynthetic Cephalosporin Antibiotics
7-Aminodesacetoxycephalosporanic acid (7-ADCA) is conventionally produced from penicillin. It is used as a starting compound for semisynthetic cephalosporin antibiotics. Differences in side chain structure at the 7-position directly affect their antibiotic activity.
References
- Industrial transformations of penicillins and cephalosporins
- Production of cephalosporin intermediates by feeding adipic acid to recombinant Penicillium chrysogenum strains expressing ring expansion activity
- Cephalosporanic acid 7β-alkylideneammonio salts
- Synthetic utility of dimethyl formaminium chloride chlorosulphate in preparation of cephems
- Efficient biocatalyst for large-scale synthesis of cephalosporins, obtained by combining immobilization and site-directed mutagenesis of penicillin acylase
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
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