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Published TCIMAIL newest issue No.197
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CAS RN: 5908-99-6 | Product Number: A0550
Atropine Sulfate Monohydrate
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Purity: >99.0%(T)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 5G |
€28.00
|
2 | 26 |
| 25G |
€88.00
|
1 | 4 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A0550 |
| Purity / Analysis Method | >99.0%(T) |
| Molecular Formula / Molecular Weight | C__3__4H__4__6N__2O__6·H__2SO__4·H__2O = 694.84 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Hygroscopic |
| CAS RN | 5908-99-6 |
| Related CAS RN | 55-48-1&51-55-8 |
| Reaxys Registry Number | 5720678 |
| PubChem Substance ID | 87562147 |
| MDL Number | MFCD00077268 |
Specifications
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Solubility in Water | almost transparency |
Properties (reference)
| Melting Point | 194 °C |
| Solubility (insoluble in) | Ether, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 + H330 : Fatal if swallowed or if inhaled. |
| Precautionary Statements | P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P264 : Wash skin thoroughly after handling. P284 : Wear respiratory protection. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. |
Related Laws:
| EC Number | 200-235-0 |
Transport Information:
| UN Number | UN1544 |
| Class | 6.1 |
| Packing Group | II |
| HS Number | 2939799090 |
Application
Atropine Sulfate: A Nonselective Muscarinic Acetylcholinergic Receptors Antagonist
Atropine sulfate is a tropane alkaloid which was first extracted from the root of belladonna (Atropa belladonna) in 1830s. Atropine sulfate is a enantiomeric mixture of (R,S)-hyoscyamine (dl-hyoscyamine), racemization occurring during the extraction procedure, whereas only (S)-hyoscyamine (l-hyoscyamine) [H0450] is the active isomer. Atropine is a competitive antagonist of muscarine-like actions of acetylcholine and is therefore classified as an antimuscarinic agent. Atropine does not distinguish among the M1, M2, and M3 subgroups of muscarinic receptors. Atropine inhibits the action of acetylcholine at postganglionic nerve endings, thus affecting receptors of the exocrine glands, smooth muscle, cardiac muscle and the central nervous system. (The product is for research purpose only.)
References
- Muscarinic antagonists in development for disorders of smooth muscle function (a review)
- Atropine (a review on the chemical and physical properties, isolation, synthesis, methods of analysis, and pharmacology of atropine)
- High-performance liquid chromatographic determination of atropine and atropine-like alkaloids in pharmaceutical preparations with indirect conductometric detection
- Determination of atropine in pharmaceutical preparations by liquid chromatography with fluorescence detection
- Analysis of atropine, its degradation products and related substances of natural origin by means of reversed-phase high-performance liquid chromatography
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