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CAS RN: 866323-14-0 | Product Number: B5888
Belinostat
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Purity: >98.0%(HPLC)
Synonyms:
- (E)-N-Hydroxy-3-[3-(N-phenylsulfamoyl)phenyl]acrylamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
125,00 €
|
1 | 16 |
|
| 100MG |
406,00 €
|
Contact Us | 12 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B5888 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__4N__2O__4S = 318.35 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 866323-14-0 |
| Reaxys Registry Number | 10087570 |
| PubChem Substance ID | 468590769 |
| MDL Number | MFCD08064035 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 160 °C(dec.) |
| Maximum Absorption Wavelength | 716 nm |
GHS
Related Laws:
Transport Information:
| HS Number | 2935909099 |
Application
Belinostat: A Class I, II and IV HDAC Inhibitor
Belinostat (PXD101) is a class I, II and IV histone deacetylase (HDAC) enzyme inhibitor with a broad antineoplastic activity. HDACs catalyze the removal of acetyl groups from the N-acetylated lysine residues of histones and some non-histone proteins. Histones are the basic protein building blocks of chromatins in the nucleus of a cell, which contain DNA coiled around the histone unit. They compact DNA into a smaller volume, and also play a role in DNA replication, repair, mitosis, and gene expression. HDAC inhibitors block angiogenesis, arrest cell growth, and lead to cell-cycle arrest and apoptosis in tumor cells. Belinostat has been used for the treatment of T-cell lymphoma (PTCL). (The product is for research purpose only.)
References
- Pharmacodynamic Response and Inhibition of Growth of Human Tumor Xenografts by the Novel Histone Deacetylase Inhibitor PXD101
- Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies
- Belinostat: First Global Approval (a review)
- Histone deacetylase inhibitors (HDACIs). Structure-activity relationships: history and new QSAR perspectives (a review)
- LC-MS/MS assay for the quantitation of the HDAC inhibitor belinostat and five major metabolites in human plasma
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