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CAS RN: 154-42-7 | Product Number: T0212
6-Thioguanine
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Purity: >95.0%(HPLC)
Synonyms:
- 2-Amino-6-mercaptopurine
- 6-Mercaptoguanine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 1G |
$103.00
|
≥40 | ≥40 |
| 5G |
$307.00
|
33 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | T0212 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__5H__5N__5S = 167.19 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 154-42-7 |
| Reaxys Registry Number | 1074099 |
| PubChem Substance ID | 87576202 |
| SDBS (AIST Spectral DB) | 4204 |
| Merck Index (14) | 9337 |
| MDL Number | MFCD00233553 |
Specifications
| Appearance | Light orange to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | UP0740000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2933.99-000 |
Application
6-Thioguanineis: A Cytotoxic Agent with Immunosuppressive and Antitumor Properties
6-Thioguanine (6-TG) is a cytotoxic agent with immunosuppressive and antitumor properties. In cell, 6-TG is converted to the active nucleotide metabolite by the enzyme hypoxanthine guanine phosphoribosyltransferase (HPRT), subsequently leading to inhibition of DNA/RNA synthesis.
References
- CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes
- The thiopurines: an update (a review)
- UVA photosensitization of thiopurines and skin cancer in organ transplant recipients (a review)
- 6-thioguanine: a drug with unrealized potential for cancer therapy (a review)
PubMed Literature
Articles/Brochures
TCIMAIL
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Safety Data Sheet (SDS)
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