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CAS RN: 3945-69-5 | Product Number: R0294
Reagents for Condensation Reactions (DMT-MM) (HPMC encapsulated)
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Purity:
Synonyms:
- DMT-MM ca. 0.30 mmol/capsule (HPMC encapsulated)
Product Documents:
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Supplemental Product Information:
Contents (per one capsule)
- DMT-MM : ca. 0.30 mmol
Directions for Use
- Each capsule contains all reagents for a single use on 0.30 mmol scale condensation reaction (amide coupling reaction) between carboxylic acid and amine.
Typical condition: 0.30 mmol of carboxylic acid and 1.05 equiv. of amines in methanol (0.20 M) at 30 °C.
Related Products
- D2919 DMT-MM
| Product Number | R0294 |
| Molecular Formula / Molecular Weight | C__1__0H__1__7ClN__4O__3 = 276.72 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 3945-69-5 |
Specifications
| Appearance | White to Almost white capsule |
| Functionality test (conversion ratio) | 85.0 %以上 |
Properties (reference)
GHS
| Pictogram |
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| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H314 : Causes severe skin burns and eye damage. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 : Wash contaminated clothing before reuse. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P405 : Store locked up. |
Related Laws:
Transport Information:
| UN Number | UN3261 |
| Class | 8 |
| Packing Group | II |
| H.S.code* | 3822.19-000 |
Application
TCI Practical Example: Condensation Reaction Using DMT-MM in a Capsule Reagent
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Used Chemicals
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Procedure
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Reagents for condensation capsule (DMT-MM) (one capsule) was added to a solution of 4-bromobenzoic acid (60 mg, 0.30 mmol, 1.0 eq.), morpholine (27.4 μL, 0.315 mmol, 1.05 eq.) in methanol (1.5 mL) at room temperature. The mixture was stirred at 30 °C for 24 hours. The reaction solution was diluted with ethyl acetate (20 mL) and filtrated through Celite pad. The filtrate was washed with sat. Na2SO4 aq. (30 mL), 1 mol/L HCl aq. (10 mL), sat. NaHCO3 aq. (15 mL) and brine (15 mL), dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel chromatography (ethyl acetate:hexane = 4:1 - 1:1) to afford (4-bromophenyl)(morpholino)methanone (70 mg, 86% yield) as a white solid.
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Experimenter’s Comments
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The reaction mixture was monitored by UPLC.
The shape of the capsule is like below image and each capsule includes DMT-MM (ca. 0.30 mmol).
The material of the capsule is water-soluble HPMC (hydroxypropyl methylcellulose).
Saturated sodium sulfate solution used during partitioning was used to remove HPMC.
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Analytical Data
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(4-Bromophenyl)(morpholino)methanone
1H NMR (400 MHz, DNSO-d6); δ 7.65 (dt, J = 8.9 Hz, 2.1 Hz, 2H), 7.37 (dt, J = 8.5 Hz, 2.1 Hz, 2H), 3.61-3.24 (brm, 8H).
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Lead Reference
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- Hydrophobic Pockets of HPMC Enable Extremely Short Reaction Times in Water
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Other Reference
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- HPMC: A Biomass-Based Semisynthetic Sustainable Additive Enabling Clean and Fast Chemistry in Water
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
C of A & Other Certificates
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Other Documents
Related Products
4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium Chloride
| Product # | D2919 |
| CAS RN | 3945-69-5 |
| Purity / Analysis Method: | >95.0%(HPLC) |