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CAS RN: 103177-37-3 | Product Number: P2115
Pranlukast
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
$46.00
|
4 | 12 | It can be shipped in about 2 weeks after ordering | |
| 100MG |
$139.00
|
17 | ≥80 | It can be shipped in about 2 weeks after ordering |
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
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| Product Number | P2115 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__7H__2__3N__5O__4 = 481.51 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 103177-37-3 |
| Reaxys Registry Number | 6548353 |
| PubChem Substance ID | 253661988 |
| Merck Index (14) | 7710 |
| MDL Number | MFCD00864631 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 14.00 to 15.00 % |
Properties (reference)
| Melting Point | 233 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Dimethylformamide |
| Solubility (insoluble in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | CV5647500 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
Pranlukast: A Cysteinyl Leukotriene (Cys-LT) Receptor Antagonist
Pranlukast (ONO-1078) is a selective and competitive antagonist of the cysteinyl leukotriene receptor (Cys-LTR). Cysteinyl leukotrienes (Cys-LTs) LTC4, LTD4 and LTE4 are potent proinflammatory mediators derived from arachidonic acid [A0781] through the 5-lypoxigenase (5-LO) pathway. Cys-LTs induce pathophysiological responses such as potent bronchoconstriction, mucus secretion, mucosal edema, vascular hyperpermeability and eosinophil infiltration. Hence, Cys-LTs are important mediators of allergy and inflammation. (The product is for research purpose only.)
References
- Pranlukast, a cysteinyl leukotriene receptor antagonist, attenuates allergen-induced early- and late-phase bronchoconstriction and airway hyperresponsiveness in asthmatic subjects
- Characterization of the human cysteinyl leukotriene CysLT1 receptor
- Determination of pranlukast and its metabolites in human plasma by LC/MS/MS with PROSPEKTTM online solid-phase extraction
- Pranlukast: A review of its use in the management of asthma
- Antileukotriene drugs: clinical application, effectiveness and safety (a review)
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