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CAS RN: 100491-29-0 | Product Number: E1180
Ethyl 7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 5G |
$33.00
|
6 | 1 |
| 25G |
$94.00
|
8 | 19 |
* Please contact our distributors or
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | E1180 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__7H__1__0ClF__3N__2O__3 = 382.72 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 100491-29-0 |
| Reaxys Registry Number | 4766094 |
| PubChem Substance ID | 253661440 |
| MDL Number | MFCD01863285 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 213.0 to 217.0 °C |
Properties (reference)
| Melting Point | 215 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H317 : May cause an allergic skin reaction. H411 : Toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P273 : Avoid release to the environment. P272 : Contaminated work clothing should not be allowed out of the workplace. P280 : Wear protective gloves. P302 + P352 : IF ON SKIN: Wash with plenty of water. P391 : Collect spillage. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| UN Number | UN3077 |
| Class | 9 |
| Packing Group | III |
| H.S.code* | 2933.99-000 |
Application
The Synthesis of Fluoroquinolone Antibiotics
This compound has previously been converted into tosufloxacin [T2506] by reaction with 3-acetamidopyrrolidine [A1108]. To this day, it has been widely used for the synthesis of fluoroquinolone antibiotics such as trovafloxacin.
References
- Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterial agents
- Preparation and in vitro and in vivo evaluation of quinolones with selective activity against Gram-positive organisms
- Synthesis of (1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hexane, a novel achiral diamine
- Diastereoselective syntheses of N-protected derivatives of 1α,5α,6β-6-amino-3-azabicyclo[3.1.0]hexane. A route to trovafloxacin 6β-diastereomer
- Synthesis of trovafloxacin using various (1α,5α,6α)-3-azabicyclo[3.1.0]hexane derivatives
PubMed Literature
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