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CAS RN: 872728-81-9 | Product Number: D6198
Dabigatran Etexilate Mesylate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- Dabigatran Etexilate Methanesulfonate
- BIBR-1048MS
- Ethyl N-[[2-[[4-[N-[(Hexyloxy)carbonyl]carbamimidoyl]anilino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-β-alaninate Methanesulfonate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
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| 1G |
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| Product Number | D6198 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__3__4H__4__1N__7O__5·CH__4O__3S = 723.85 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 872728-81-9 |
| Reaxys Registry Number | 15471668 |
| MDL Number | MFCD17215180 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. H362 : May cause harm to breast-fed children. H373 : May cause damage to organs through prolonged or repeated exposure. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy and while nursing. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | AY3157700 |
Transport Information:
| H.S.code* | 2933.39-000 |
Application
Dabigatran Etexilate Mesylate: An Oral, Reversible Direct Thrombin Inhibitor
Dabigatran etexilate [D5904] and its mesylate are oral, reversible direct thrombin inhibitors and prodrugs of dabigatran [D5902]. Thrombin enables the conversion of fibrinogen into fibrin during the blood coagulation cascade. Inhibition prevents the formation of a thrombus. Therefore, thrombin-induced platelet aggregation is inhibited by the active metabolite dabigatran. It is used clinically as an alternative to warfarin [W0005] and does not require monitoring of coagulation parameters by blood tests. (The product is for research purpose only.)
References
- Dabigatran etexilate - a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity (a review)
- Development of liquid chromatographic method for the analysis of dabigatran etexilate mesylate and its ten impurities supported by quality-by-design methodology
- Solubility measurement, correlation and molecular simulation of dabigatran etexilate mesylate polymorphs in five mono-solvents
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