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CAS RN: 29767-20-2 | Product Number: T3109
Teniposide
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 20MG |
€ 43,00
|
1 | ≥60 |
|
| 100MG |
€ 158,00
|
2 | 17 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3109 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__2H__3__2O__1__3S = 656.66 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 20MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 29767-20-2 |
| Reaxys Registry Number | 7108452 |
| PubChem Substance ID | 253662241 |
| Merck Index (14) | 9145 |
| MDL Number | MFCD00866516 |
Specifications
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -107.0 to -115.0 deg(C=1, CHCl3:MeOH=9:1) |
Properties (reference)
| Melting Point | 247 °C(dec.) |
| Specific Rotation | -111° (C=1,CHCl3:MeOH=9:1) |
| Maximum Absorption Wavelength | 283(MeOH) nm |
| Solubility in water | Insoluble |
| Degree of solubility in water | 5.9 mg/l 25 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. H371 : May cause damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H341 : Suspected of causing genetic defects. H350 : May cause cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. |
Related Laws:
| EC Number | 249-831-2 |
| RTECS# | KC0180000 |
Transport Information:
| HS Number | 2938909090 |
Application
Adeno-associated virus vector transduction enhancer
Teniposide exhibits enhancement of adeno-associated virus transduction.1)
References
- 1) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens
Application
Teniposide: An Inhibitor of Topoisomerase II
Teniposide (VM26) and etoposide (VP16-213) [E0675] are semisynthetic derivatives of podophyllotoxin [P1771], an alkaloid. Teniposide and teniposide are an inhibitor of topoisomerase II such as doxorubicin [D4193], daunorubicin [D4532]. Topoisomerase II is an enzyme essential for DNA replication, chromosome condensation and chromosome segregation. Topoisomerase II inhibitors are potent inducers of double strand breaks in DNA, and can cause arrest in the cell cycle at the G2 stage. Therefore, topoisomerase II inhibitors are the most widely used anti-cancer agents. Teniposide is used for the treatment of acute lymphocytic leukemia (ALL). (The product is for research purpose only.)
References
- The podophyllotoxin derivatives VP16-213 and VM26 (a review)
- The clinical pharmacology of etoposide and teniposide (a review)
- Clinical applications of anticancer drugs targeted to topoisomerase II
- Podophyllotoxin (a review)
- Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents
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