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Published TCIMAIL newest issue No.197
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CAS RN: 22189-32-8 | Product Number: S0584
Spectinomycin Dihydrochloride Pentahydrate
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Purity: >98.0%(T)(N)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€56.00
|
8 | ≥100 |
|
| 25G |
€178.00
|
6 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | S0584 |
| Purity / Analysis Method | >98.0%(T)(N) |
| Molecular Formula / Molecular Weight | C__1__4H__2__4N__2O__7·2HCl·5H__2O = 495.35 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 22189-32-8 |
| Related CAS RN | 21736-83-4&1695-77-8 |
| PubChem Substance ID | 354335325 |
| Merck Index (14) | 8739 |
| MDL Number | MFCD00150886 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Purity(Argentometric Titration) | min. 98.0 % |
| Specific rotation [a]20/D | +15.0 to +21.0 deg(C=1,H2O) |
| Water | 16.0 to 20.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 207 °C(dec.) |
| Specific Rotation | 15° (C=1,H2O) |
| Solubility (insoluble in) | Ethanol |
GHS
Related Laws:
| RTECS# | WG7400000 |
Transport Information:
| HS Number | 2941900000 |
Application
Spectinomycin Dihydrochloride: An Aminocyclitol Antibiotic Used for the Treatment of Infection with Streptomyces spectabilis and for Molecular Cloning
Spectinomycin dihydrochloride is an aminoglycoside antibiotic produced by a species of soil microorganism designated as Streptomyces spectabilis. Spectinomycin exerts its bactericidal activity by inhibiting protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit. Spectinomycin is highly effective for the treatment of infections with Neisseria gonorrhoeae. In vitro studies have shown no cross-resistance of Neisseria gonorrhoeae between spectinomycin hydrochloride and benzylpenicillins [A2092] [P1770] [P1772]. On bioscience research, a resistance-conferring gene for spectinomycin can also be used as a selection marker in bacteria for molecular cloning purposes. In addition, spectinomycin is used as a selection agent for transformed plant cells that contain the selectable marker gene SpcR. (The product is for research purpose only.)
References
- Spectinomycin (a review on the structure, antibacterial activity, and mechanisms of resistance of spectinomycin)
- Chemistry of spectinomycin: its total synthesis, stereocontrolled rearrangement, and analogs
- Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics
- Human safety and genetically modified plants: a review of antibiotic resistance markers and future transformation selection technologies
- Plastid transformation in flowering plants (a review)
- Spontaneous and induced mutations to rifampicin, streptomycin and spectinomycin resistances in actinomycetes: mutagenic mechanisms and applications for strain improvement (a review)
- Determination of spectinomycin hydrochloride and its related substances by HPLC-ELSD and HPLC-MSn
- Development and validation of liquid chromatography tandem mass spectrometry methods for the determination of gentamicin, lincomycin, and spectinomycin in the presence of their impurities in pharmaceutical formulations
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