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Published TCIMAIL newest issue No.197
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CAS RN: 113-52-0 | Product Number: I0971
Imipramine Hydrochloride
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Purity: >98.0%(HPLC)
Synonyms:
- 10,11-Dihydro-N,N-dimethyl-5H-dibenzo[b,f]azepine-5-propanamine Hydrochloride
- 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenzo[b,f]azepine Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
33,00 €
|
2 | ≥100 |
|
| 5G |
126,00 €
|
Contact Us | 30 |
|
| 25G |
501,00 €
|
3 | Contact Us |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | I0971 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__4N__2·HCl = 316.87 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 113-52-0 |
| Related CAS RN | 50-49-7 |
| Reaxys Registry Number | 3576963 |
| PubChem Substance ID | 253661339 |
| Merck Index (14) | 4920 |
| MDL Number | MFCD00012669 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 171.0 to 175.0 °C |
Properties (reference)
| Melting Point | 173 °C |
| Maximum Absorption Wavelength | 260 nm |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 204-030-7 |
| RTECS# | HO1925000 |
Transport Information:
| HS Number | 2933998090 |
Application
Imipramine hydrochloride: An Inhibitor of Serotonin or Noradrenaline Re-Uptake Transporters
Imipramine hydrochloride is the first tricyclic antidepressant agent synthesized in 1948. Imipramine works as an inhibitor of serotonin (5-hydroxytryptamine, 5HT [S0370]) or L-noradrenaline [A0906] re-uptake transporters in brain neurons, but it also inhibits the release of acetylcholine from nerves. (The product is for research purpose only.)
References
- Inhibition of the uptake of tritiated catechol amines by antidepressant and related agents
- "Behavioral despair" in rats and mice: strain differences and the effects of imipramine
- Imipramine hydrochloride (a review)
- Transdermal drug delivery of imipramine hydrochloride. I. Effect of terpenes
- Depression and antidepressants: Insights from knockout of dopamine, serotonin or noradrenaline re-uptake transporters (a review)
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