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Published TCIMAIL newest issue No.197
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CAS RN: 22465-48-1 | Product Number: H1542
Hydroxocobalamin Acetate
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Purity: >90.0%(HPLC)
Synonyms:
- Vitamin B12a Acetate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€118.00
|
4 | ≥100 |
|
| 5G |
€408.00
|
1 | 15 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | H1542 |
| Purity / Analysis Method | >90.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__6__4H__9__1CoN__1__3O__1__6P = 1,388.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 22465-48-1 |
| Reaxys Registry Number | 19236547 |
| PubChem Substance ID | 253661238 |
| Merck Index (14) | 4809 |
| MDL Number | MFCD00082532 |
Specifications
| Appearance | Orange to Brown to Dark red powder to crystal |
| Purity(HPLC) | min. 90.0 area% |
| Purity(Chelometric Titration) | min. 95.0 %(calcd.on dried substance) |
| Drying loss | max. 12.0 % |
Properties (reference)
| Maximum Absorption Wavelength | 350(AcOH buffer Sol. pH4.5) nm |
| Solubility (insoluble in) | Ether |
GHS
Related Laws:
| EC Number | 245-019-7 |
| RTECS# | GG3740000 |
Transport Information:
| HS Number | 2936260000 |
Application
Hydroxocobalamin Acetate: Long Acting Vitamin B12 Physiological Equivalent Form
Vitamin B12 exists in four major physiological equivalent forms referred to collectively as cobalamins; hydroxocobalamin acetate, cyanocobalamin [C0449], methylcobalamin [M2742], and 5’-deoxyadenosylcobalamine. An intramuscular injection of hydroxocobalamin acetate produces higher serum levels than the same dose of cyanocobalamin, and these levels are well maintained. Cobalamins function as a coenzyme in a number of reactions, including the oxidation of fatty acids and the synthesis of DNA. They also works in conjugation with folic acid [F0043] (Vitamin B9) in the synthesis of the amino acid L-methionine [M0099] and it required for normal production of red blood cells. Although cobalamins are necessary for nervous system maintenance, the mechanisms are not entirely known. Cobalamins can be used to prevent or treat pathology arising from a lack of vitamin B12. (The product is for research purpose only.)
References
- Differential effects of hydroxocobalamin on NO-mediated relaxations in rat aorta and anococcygeus muscle
- Differential effects of hydroxocobalamin on relaxations induced by nitrosothiols in rat aorta and anococcygeus muscle
- Hematopoietic Vitamins with Special Reference to Vitamin B12 and Folic Acid in Clinical Field
- H. Uchino, Acta Haemat. Jpn. 1966, 29, 491.
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